Pervasive chromosomal instability and karyotype order in tumour evolution

Chromosomal instability in cancer consists of dynamic changes to the number and structure of chromosomes(1,2). The resulting diversity in somatic copy number alterations (SCNAs) may provide the variation necessary for tumour evolution(1,3,4). Here we use multi-sample phasing and SCNA analysis of 1,4...

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Pubblicato in:Nature
Autori principali: Watkins, Thomas B. K., Lim, Emilia L., Petkovic, Marina, Elizalde, Sergi, Birkbak, Nicolai J., Wilson, Gareth A., Moore, David A., Grönroos, Eva, Rowan, Andrew, Dewhurst, Sally M., Demeulemeester, Jonas, Dentro, Stefan C., Horswell, Stuart, Au, Lewis, Haase, Kerstin, Escudero, Mickael, Rosenthal, Rachel, Al Bakir, Maise, Xu, Hang, Litchfield, Kevin, Lu, Wei Ting, Mourikis, Thanos P., Dietzen, Michelle, Spain, Lavinia, Cresswell, George D., Biswas, Dhruva, Lamy, Philippe, Nordentoft, Iver, Harbst, Katja, Castro-Giner, Francesc, Yates, Lucy R., Caramia, Franco, Jaulin, Fanny, Vicier, Cécile, Tomlinson, Ian P. M., Brastianos, Priscilla K., Cho, Raymond J., Bastian, Boris C., Dyrskjøt, Lars, Jönsson, Göran B., Savas, Peter, Loi, Sherene, Campbell, Peter J., Andre, Fabrice, Luscombe, Nicholas M., Steeghs, Neeltje, Tjan-Heijnen, Vivianne C. G., Szallasi, Zoltan, Turajlic, Samra, Jamal-Hanjani, Mariam, Van Loo, Peter, Bakhoum, Samuel F., Schwarz, Roland F., McGranahan, Nicholas, Swanton, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611706/
https://ncbi.nlm.nih.gov/pubmed/32879494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2698-6
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