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Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

Deciphering whether actionable driver mutations are found in all or a subset of tumor cells will likely be required to improve drug development and precision medicine strategies. We analyzed nine cancer types to determine the subclonal frequencies of driver events, to time mutational processes durin...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: McGranahan, Nicholas, Favero, Francesco, de Bruin, Elza C., Birkbak, Nicolai Juul, Szallasi, Zoltan, Swanton, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636056/
https://ncbi.nlm.nih.gov/pubmed/25877892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa1408
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