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Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
Deciphering whether actionable driver mutations are found in all or a subset of tumor cells will likely be required to improve drug development and precision medicine strategies. We analyzed nine cancer types to determine the subclonal frequencies of driver events, to time mutational processes durin...
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| Veröffentlicht in: | Sci Transl Med |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4636056/ https://ncbi.nlm.nih.gov/pubmed/25877892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa1408 |
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