Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome

BACKGROUND: Glioblastoma (GBM) is the most common malignant brain cancer occurring in adults, and is associated with dismal outcome and few therapeutic options. GBM has been shown to predominantly disrupt three core pathways through somatic aberrations, rendering it ideal for precision medicine appr...

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Publicado en:Ann Oncol
Main Authors: Favero, F., McGranahan, N., Salm, M., Birkbak, N. J., Sanborn, J. Z., Benz, S. C., Becq, J., Peden, J. F., Kingsbury, Z., Grocok, R. J., Humphray, S., Bentley, D., Spencer-Dene, B., Gutteridge, A., Brada, M., Roger, S., Dietrich, P.-Y., Forshew, T., Gerlinger, M., Rowan, A., Stamp, G., Eklund, A. C., Szallasi, Z., Swanton, C.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405282/
https://ncbi.nlm.nih.gov/pubmed/25732040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdv127
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