Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome

BACKGROUND: Glioblastoma (GBM) is the most common malignant brain cancer occurring in adults, and is associated with dismal outcome and few therapeutic options. GBM has been shown to predominantly disrupt three core pathways through somatic aberrations, rendering it ideal for precision medicine appr...

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Publicat a:Ann Oncol
Autors principals: Favero, F., McGranahan, N., Salm, M., Birkbak, N. J., Sanborn, J. Z., Benz, S. C., Becq, J., Peden, J. F., Kingsbury, Z., Grocok, R. J., Humphray, S., Bentley, D., Spencer-Dene, B., Gutteridge, A., Brada, M., Roger, S., Dietrich, P.-Y., Forshew, T., Gerlinger, M., Rowan, A., Stamp, G., Eklund, A. C., Szallasi, Z., Swanton, C.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405282/
https://ncbi.nlm.nih.gov/pubmed/25732040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdv127
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