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Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine

The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial des...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Hiley, Crispin, de Bruin, Elza C, McGranahan, Nicholas, Swanton, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281956/
https://ncbi.nlm.nih.gov/pubmed/25222836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0453-8
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