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Interplay between whole genome doubling and the accumulation of deleterious alterations in cancer evolution
Whole genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the entire chromosome complement. However, despite its prevalence and prognostic relevance, the evolutionary selection pressures for WGD have not been investigated. Here, we combine evolutionary simulations with an a...
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| Publicado en: | Nat Genet |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7116784/ https://ncbi.nlm.nih.gov/pubmed/32139907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0584-7 |
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