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Interplay between whole genome doubling and the accumulation of deleterious alterations in cancer evolution
Whole genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the entire chromosome complement. However, despite its prevalence and prognostic relevance, the evolutionary selection pressures for WGD have not been investigated. Here, we combine evolutionary simulations with an a...
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| Publicado no: | Nat Genet |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7116784/ https://ncbi.nlm.nih.gov/pubmed/32139907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0584-7 |
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