Interplay between whole genome doubling and the accumulation of deleterious alterations in cancer evolution

Whole genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the entire chromosome complement. However, despite its prevalence and prognostic relevance, the evolutionary selection pressures for WGD have not been investigated. Here, we combine evolutionary simulations with an a...

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Publicado en:Nat Genet
Autores principales: López, Saioa, Lim, Emilia L., Horswell, Stuart, Haase, Kerstin, Huebner, Ariana, Dietzen, Michelle, Mourikis, Thanos P., Watkins, Thomas B.K., Rowan, Andrew, Dewhurst, Sally M., Birkbak, Nicolai J., Wilson, Gareth A., Van Loo, Peter, Jamal-Hanjani, Mariam, Swanton, Charles, McGranahan, Nicholas
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116784/
https://ncbi.nlm.nih.gov/pubmed/32139907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0584-7
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