Interplay between whole genome doubling and the accumulation of deleterious alterations in cancer evolution

Whole genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the entire chromosome complement. However, despite its prevalence and prognostic relevance, the evolutionary selection pressures for WGD have not been investigated. Here, we combine evolutionary simulations with an a...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: López, Saioa, Lim, Emilia L., Horswell, Stuart, Haase, Kerstin, Huebner, Ariana, Dietzen, Michelle, Mourikis, Thanos P., Watkins, Thomas B.K., Rowan, Andrew, Dewhurst, Sally M., Birkbak, Nicolai J., Wilson, Gareth A., Van Loo, Peter, Jamal-Hanjani, Mariam, Swanton, Charles, McGranahan, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116784/
https://ncbi.nlm.nih.gov/pubmed/32139907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0584-7
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