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Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis. Here, we present loss of heterozygosity in human l...

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Библиографические подробности
Опубликовано в: :Cell
Главные авторы: McGranahan, Nicholas, Rosenthal, Rachel, Hiley, Crispin T., Rowan, Andrew J., Watkins, Thomas B.K., Wilson, Gareth A., Birkbak, Nicolai J., Veeriah, Selvaraju, Van Loo, Peter, Herrero, Javier, Swanton, Charles
Формат: Artigo
Язык:Inglês
Опубликовано: Cell Press 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720478/
https://ncbi.nlm.nih.gov/pubmed/29107330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.10.001
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