Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis. Here, we present loss of heterozygosity in human l...

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Publicado no:Cell
Main Authors: McGranahan, Nicholas, Rosenthal, Rachel, Hiley, Crispin T., Rowan, Andrew J., Watkins, Thomas B.K., Wilson, Gareth A., Birkbak, Nicolai J., Veeriah, Selvaraju, Van Loo, Peter, Herrero, Javier, Swanton, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720478/
https://ncbi.nlm.nih.gov/pubmed/29107330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.10.001
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