Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis. Here, we present loss of heterozygosity in human l...

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Détails bibliographiques
Publié dans:Cell
Auteurs principaux: McGranahan, Nicholas, Rosenthal, Rachel, Hiley, Crispin T., Rowan, Andrew J., Watkins, Thomas B.K., Wilson, Gareth A., Birkbak, Nicolai J., Veeriah, Selvaraju, Van Loo, Peter, Herrero, Javier, Swanton, Charles
Format: Artigo
Langue:Inglês
Publié: Cell Press 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720478/
https://ncbi.nlm.nih.gov/pubmed/29107330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.10.001
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