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deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

BACKGROUND: Analysis of somatic mutations provides insight into the mutational processes that have shaped the cancer genome, but such analysis currently requires large cohorts. We develop deconstructSigs, which allows the identification of mutational signatures within a single tumor sample. RESULTS:...

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Bibliografski detalji
Izdano u:Genome Biol
Glavni autori: Rosenthal, Rachel, McGranahan, Nicholas, Herrero, Javier, Taylor, Barry S., Swanton, Charles
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4762164/
https://ncbi.nlm.nih.gov/pubmed/26899170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0893-4
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