Chromothripsis and telomere crisis: engines of genome instability

por Dewhurst, Sally M
Publicado en Curr Opin Genet Dev (2020)

Structural variant evolution after telomere crisis

por Dewhurst, Sally M., Yao, Xiaotong, Rosiene, Joel, Tian, Huasong, Behr, Julie, Bosco, Nazario, Takai, Kaori K., de Lange, Titia, Imieliński, Marcin
Publicado en Nat Commun (2021)

Tolerance whole of genome doubling propagates chromosomal instability and accelerates cancer genome evolution

por Dewhurst, Sally M, McGranahan, Nicholas, Burrell, Rebecca A, Rowan, Andrew J, Grönroos, Eva, Endesfelder, David, Joshi, Tejal, Mouradov, Dmitri, Gibbs, Peter, Ward, Robyn L., Hawkins, Nicholas J., Szallasi, Zoltan, Sieber, Oliver M., Swanton, Charles
Publicado en Cancer Discov (2014)

Interplay between whole genome doubling and the accumulation of deleterious alterations in cancer evolution

por López, Saioa, Lim, Emilia L., Horswell, Stuart, Haase, Kerstin, Huebner, Ariana, Dietzen, Michelle, Mourikis, Thanos P., Watkins, Thomas B.K., Rowan, Andrew, Dewhurst, Sally M., Birkbak, Nicolai J., Wilson, Gareth A., Van Loo, Peter, Jamal-Hanjani, Mariam, Swanton, Charles, McGranahan, Nicholas
Publicado en Nat Genet (2020)

Replication stress links structural and numerical cancer chromosomal instability

por Burrell, Rebecca A., McClelland, Sarah E., Endesfelder, David, Groth, Petra, Weller, Marie-Christine, Shaikh, Nadeem, Domingo, Enric, Kanu, Nnennaya, Dewhurst, Sally M., Gronroos, Eva, Chew, Su Kit, Rowan, Andrew J., Schenk, Arne, Sheffer, Michal, Howell, Michael, Kschischo, Maik, Behrens, Axel, Helleday, Thomas, Bartek, Jiri, Tomlinson, Ian P., Swanton, Charles
Publicado en Nature (2013)

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

por Berenjeno, Inma M., Piñeiro, Roberto, Castillo, Sandra D., Pearce, Wayne, McGranahan, Nicholas, Dewhurst, Sally M., Meniel, Valerie, Birkbak, Nicolai J., Lau, Evelyn, Sansregret, Laurent, Morelli, Daniele, Kanu, Nnennaya, Srinivas, Shankar, Graupera, Mariona, Parker, Victoria E. R., Montgomery, Karen G., Moniz, Larissa S., Scudamore, Cheryl L., Phillips, Wayne A., Semple, Robert K., Clarke, Alan, Swanton, Charles, Vanhaesebroeck, Bart
Publicado en Nat Commun (2017)

Pervasive chromosomal instability and karyotype order in tumour evolution

por Watkins, Thomas B. K., Lim, Emilia L., Petkovic, Marina, Elizalde, Sergi, Birkbak, Nicolai J., Wilson, Gareth A., Moore, David A., Grönroos, Eva, Rowan, Andrew, Dewhurst, Sally M., Demeulemeester, Jonas, Dentro, Stefan C., Horswell, Stuart, Au, Lewis, Haase, Kerstin, Escudero, Mickael, Rosenthal, Rachel, Al Bakir, Maise, Xu, Hang, Litchfield, Kevin, Lu, Wei Ting, Mourikis, Thanos P., Dietzen, Michelle, Spain, Lavinia, Cresswell, George D., Biswas, Dhruva, Lamy, Philippe, Nordentoft, Iver, Harbst, Katja, Castro-Giner, Francesc, Yates, Lucy R., Caramia, Franco, Jaulin, Fanny, Vicier, Cécile, Tomlinson, Ian P. M., Brastianos, Priscilla K., Cho, Raymond J., Bastian, Boris C., Dyrskjøt, Lars, Jönsson, Göran B., Savas, Peter, Loi, Sherene, Campbell, Peter J., Andre, Fabrice, Luscombe, Nicholas M., Steeghs, Neeltje, Tjan-Heijnen, Vivianne C. G., Szallasi, Zoltan, Turajlic, Samra, Jamal-Hanjani, Mariam, Van Loo, Peter, Bakhoum, Samuel F., Schwarz, Roland F., McGranahan, Nicholas, Swanton, Charles
Publicado en Nature (2020)