Pervasive chromosomal instability and karyotype order in tumour evolution

Chromosomal instability in cancer consists of dynamic changes to the number and structure of chromosomes(1,2). The resulting diversity in somatic copy number alterations (SCNAs) may provide the variation necessary for tumour evolution(1,3,4). Here we use multi-sample phasing and SCNA analysis of 1,4...

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Publicat a:Nature
Autors principals: Watkins, Thomas B. K., Lim, Emilia L., Petkovic, Marina, Elizalde, Sergi, Birkbak, Nicolai J., Wilson, Gareth A., Moore, David A., Grönroos, Eva, Rowan, Andrew, Dewhurst, Sally M., Demeulemeester, Jonas, Dentro, Stefan C., Horswell, Stuart, Au, Lewis, Haase, Kerstin, Escudero, Mickael, Rosenthal, Rachel, Al Bakir, Maise, Xu, Hang, Litchfield, Kevin, Lu, Wei Ting, Mourikis, Thanos P., Dietzen, Michelle, Spain, Lavinia, Cresswell, George D., Biswas, Dhruva, Lamy, Philippe, Nordentoft, Iver, Harbst, Katja, Castro-Giner, Francesc, Yates, Lucy R., Caramia, Franco, Jaulin, Fanny, Vicier, Cécile, Tomlinson, Ian P. M., Brastianos, Priscilla K., Cho, Raymond J., Bastian, Boris C., Dyrskjøt, Lars, Jönsson, Göran B., Savas, Peter, Loi, Sherene, Campbell, Peter J., Andre, Fabrice, Luscombe, Nicholas M., Steeghs, Neeltje, Tjan-Heijnen, Vivianne C. G., Szallasi, Zoltan, Turajlic, Samra, Jamal-Hanjani, Mariam, Van Loo, Peter, Bakhoum, Samuel F., Schwarz, Roland F., McGranahan, Nicholas, Swanton, Charles
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611706/
https://ncbi.nlm.nih.gov/pubmed/32879494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2698-6
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