Replication stress links structural and numerical cancer chromosomal instability

Cancer chromosomal instability (CIN) results in an elevated rate of change of chromosome number and structure and generates intratumour heterogeneity(1,2). CIN is observed in the majority of solid tumours and is associated with both poor prognosis and drug resistance(3,4). Therefore, understanding a...

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Pubblicato in:Nature
Autori principali: Burrell, Rebecca A., McClelland, Sarah E., Endesfelder, David, Groth, Petra, Weller, Marie-Christine, Shaikh, Nadeem, Domingo, Enric, Kanu, Nnennaya, Dewhurst, Sally M., Gronroos, Eva, Chew, Su Kit, Rowan, Andrew J., Schenk, Arne, Sheffer, Michal, Howell, Michael, Kschischo, Maik, Behrens, Axel, Helleday, Thomas, Bartek, Jiri, Tomlinson, Ian P., Swanton, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636055/
https://ncbi.nlm.nih.gov/pubmed/23446422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11935
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