Replication stress links structural and numerical cancer chromosomal instability

Cancer chromosomal instability (CIN) results in an elevated rate of change of chromosome number and structure and generates intratumour heterogeneity(1,2). CIN is observed in the majority of solid tumours and is associated with both poor prognosis and drug resistance(3,4). Therefore, understanding a...

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Publicado no:Nature
Main Authors: Burrell, Rebecca A., McClelland, Sarah E., Endesfelder, David, Groth, Petra, Weller, Marie-Christine, Shaikh, Nadeem, Domingo, Enric, Kanu, Nnennaya, Dewhurst, Sally M., Gronroos, Eva, Chew, Su Kit, Rowan, Andrew J., Schenk, Arne, Sheffer, Michal, Howell, Michael, Kschischo, Maik, Behrens, Axel, Helleday, Thomas, Bartek, Jiri, Tomlinson, Ian P., Swanton, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636055/
https://ncbi.nlm.nih.gov/pubmed/23446422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11935
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