Chromosomal Instability Confers Intrinsic Multi-Drug Resistance

Aneuploidy is associated with poor prognosis in solid tumours. Spontaneous chromosome mis-segregation events in aneuploid cells promote Chromosomal Instability (CIN) that may contribute to the acquisition of multi-drug resistance in vitro and heighten risk for tumour relapse in animal models. Identi...

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Detalhes bibliográficos
Main Authors: Lee, Alvin J X, Endesfelder, David, Rowan, Andrew J, Walther, Axel, Birkbak, Nicolai J, Futreal, P Andrew, Downward, Julian, Szallasi, Zoltan, Tomlinson, Ian P M, Kschischo, Maik, Swanton, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059493/
https://ncbi.nlm.nih.gov/pubmed/21363922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3604
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