Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer

BACKGROUND: Chromosomal instability (CIN) is thought to be associated with poor prognosis in solid tumours, however, evidence from pre-clinical and mouse tumour models suggest that CIN may paradoxically enhance or impair cancer cell fitness. Breast cancer prognostic expression signature sets, which...

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Hauptverfasser: Roylance, Rebecca, Endesfelder, David, Gorman, Patricia, Burrell, Rebecca A., Sander, Jil, Tomlinson, Ian, Hanby, Andrew M, Speirs, Valerie, Richardson, Andrea L., Birkbak, Nicolai J., Eklund, Aron C., Downward, Julian, Kschischo, Maik, Szallasi, Zoltan, Swanton, Charles
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199437/
https://ncbi.nlm.nih.gov/pubmed/21784954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-11-0343
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