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Paradoxical relationship between chromosomal instability and survival outcome in cancer

Chromosomal instability (CIN) is associated with poor prognosis in human cancer. However, in certain animal tumour models elevated CIN negatively impacts upon organism fitness, and is poorly tolerated by cancer cells. To better understand this seemingly contradictory relationship between CIN and can...

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Detalhes bibliográficos
Main Authors: Birkbak, Nicolai J., Eklund, Aron C., Li, Qiyuan, McClelland, Sarah E., Endesfelder, David, Tan, Patrick, Tan, Iain B, Richardson, Andrea L., Szallasi, Zoltan, Swanton, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096721/
https://ncbi.nlm.nih.gov/pubmed/21270108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3667
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