Paradoxical relationship between chromosomal instability and survival outcome in cancer

Chromosomal instability (CIN) is associated with poor prognosis in human cancer. However, in certain animal tumour models elevated CIN negatively impacts upon organism fitness, and is poorly tolerated by cancer cells. To better understand this seemingly contradictory relationship between CIN and can...

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Main Authors: Birkbak, Nicolai J., Eklund, Aron C., Li, Qiyuan, McClelland, Sarah E., Endesfelder, David, Tan, Patrick, Tan, Iain B, Richardson, Andrea L., Szallasi, Zoltan, Swanton, Charles
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096721/
https://ncbi.nlm.nih.gov/pubmed/21270108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3667
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