Chromosomal instability determines taxane response

Microtubule-stabilizing (MTS) agents, such as taxanes, are important chemotherapeutics with a poorly understood mechanism of action. We identified a set of genes repressed in multiple cell lines in response to MTS agents and observed that these genes are overexpressed in tumors exhibiting chromosoma...

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Detalhes bibliográficos
Main Authors: Swanton, Charles, Nicke, Barbara, Schuett, Marion, Eklund, Aron C., Ng, Charlotte, Li, Qiyuan, Hardcastle, Thomas, Lee, Alvin, Roy, Rajat, East, Philip, Kschischo, Maik, Endesfelder, David, Wylie, Paul, Kim, Se Nyun, Chen, Jie-Guang, Howell, Michael, Ried, Thomas, Habermann, Jens K., Auer, Gert, Brenton, James D., Szallasi, Zoltan, Downward, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688979/
https://ncbi.nlm.nih.gov/pubmed/19458043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811835106
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