Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

Intestinal organoids capture essential features of the intestinal epithelium such as crypt folding, cellular compartmentalization and collective movements. Each of these processes and their coordination require patterned forces that are currently unknown. Here we map three-dimensional cellular force...

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Veröffentlicht in:Nat Cell Biol
Hauptverfasser: Pérez-González, Carlos, Ceada, Gerardo, Greco, Francesco, Matejčić, Marija, Gómez-González, Manuel, Castro, Natalia, Menendez, Anghara, Kale, Sohan, Krndija, Denis, Clark, Andrew G., Gannavarapu, Venkata Ram, Álvarez-Varela, Adrián, Roca-Cusachs, Pere, Batlle, Eduard, Vignjevic, Danijela Matic, Arroyo, Marino, Trepat, Xavier
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611697/
https://ncbi.nlm.nih.gov/pubmed/34155382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-021-00699-6
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