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Engineered glycocalyx regulates stem cell proliferation in murine crypt organoids

At the base of the intestinal crypt, long-lived Lgr5(+) stem cells are intercalated by Paneth cells that provide essential niche signals for stem-cell maintenance. This unique epithelial anatomy makes the intestinal crypt one of the most accessible models for the study of adult stem cell biology. Th...

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Bibliographic Details
Published in:Cell Chem Biol
Main Authors: Rouhanifard, Sara H., Lopez Aguilar, Aime, Meng, Lu, Moremen, Kelley W., Wu, Peng
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910180/
https://ncbi.nlm.nih.gov/pubmed/29429899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.01.010
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