Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM

Nanobodies are popular and versatile tools for structural biology. They have a compact single immunoglobulin domain organization, bind target proteins with high affinities while reducing their conformational heterogeneity, and stabilize multi-protein complexes. Here we demonstrate that engineered na...

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Udgivet i:Nat Methods
Main Authors: Uchański, Tomasz, Masiulis, Simonas, Fischer, Baptiste, Kalichuk, Valentina, López-Sánchez, Uriel, Zarkadas, Eleftherios, Weckener, Miriam, Sente, Andrija, Ward, Philip, Wohlkönig, Alexandre, Zögg, Thomas, Remaut, Han, Naismith, James H., Nury, Hugues, Vranken, Wim, Aricescu, A. Radu, Pardon, Els, Steyaert, Jan
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611088/
https://ncbi.nlm.nih.gov/pubmed/33408403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-020-01001-6
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