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Structural basis for GABA(A) receptor potentiation by neurosteroids
Type-A γ-aminobutyric acid receptors (GABA(A)Rs) are the principal mediators of inhibitory neurotransmission in the human brain. Endogenous neurosteroids interact with GABA(A)Rs to regulate acute and chronic anxiety and are potent sedative, analgesic, anticonvulsant and anaesthetic agents. Their mod...
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| Publicado no: | Nat Struct Mol Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6166781/ https://ncbi.nlm.nih.gov/pubmed/28991263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3484 |
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