Structural basis of neurosteroid anesthetic action on GABA(A) receptors

Type A γ-aminobutyric acid receptors (GABA(A)Rs) are inhibitory pentameric ligand-gated ion channels in the brain. Many anesthetics and neurosteroids act through binding to the GABA(A)R transmembrane domain (TMD), but the structural basis of their actions is not well understood and no resting-state...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Chen, Qiang, Wells, Marta M., Arjunan, Palaniappa, Tillman, Tommy S., Cohen, Aina E., Xu, Yan, Tang, Pei
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162318/
https://ncbi.nlm.nih.gov/pubmed/30266951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06361-4
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