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Structural basis of neurosteroid anesthetic action on GABA(A) receptors
Type A γ-aminobutyric acid receptors (GABA(A)Rs) are inhibitory pentameric ligand-gated ion channels in the brain. Many anesthetics and neurosteroids act through binding to the GABA(A)R transmembrane domain (TMD), but the structural basis of their actions is not well understood and no resting-state...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6162318/ https://ncbi.nlm.nih.gov/pubmed/30266951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06361-4 |
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