GABA(A) receptor signalling mechanisms revealed by structural pharmacology

Type-A γ-aminobutyric receptors (GABA(A)Rs) are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs in clinical use and common substances of abuse. Without reliable structural...

Full description

Saved in:
Bibliographic Details
Published in:Nature
Main Authors: Masiulis, Simonas, Desai, Rooma, Uchański, Tomasz, Martin, Itziar Serna, Laverty, Duncan, Karia, Dimple, Malinauskas, Tomas, Zivanov, Jasenko, Pardon, Els, Kotecha, Abhay, Steyaert, Jan, Miller, Keith W., Aricescu, A. Radu
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370056/
https://ncbi.nlm.nih.gov/pubmed/30602790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0832-5
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items