GABA(A) receptor signalling mechanisms revealed by structural pharmacology

Type-A γ-aminobutyric receptors (GABA(A)Rs) are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs in clinical use and common substances of abuse. Without reliable structural...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Nature
Auteurs principaux: Masiulis, Simonas, Desai, Rooma, Uchański, Tomasz, Martin, Itziar Serna, Laverty, Duncan, Karia, Dimple, Malinauskas, Tomas, Zivanov, Jasenko, Pardon, Els, Kotecha, Abhay, Steyaert, Jan, Miller, Keith W., Aricescu, A. Radu
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370056/
https://ncbi.nlm.nih.gov/pubmed/30602790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0832-5
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires