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Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM
Nanobodies are popular and versatile tools for structural biology. They have a compact single immunoglobulin domain organization, bind target proteins with high affinities while reducing their conformational heterogeneity, and stabilize multi-protein complexes. Here we demonstrate that engineered na...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Nat Methods |
|---|---|
| Prif Awduron: | , , , , , , , , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2021
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7611088/ https://ncbi.nlm.nih.gov/pubmed/33408403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-020-01001-6 |
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