Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells

The acid sphingomyelinase/ceramide system plays an important role in bacterial and viral infections. Here, we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline or genetic downregulation of the e...

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Опубликовано в: :Cell Rep Med
Главные авторы: Carpinteiro, Alexander, Edwards, Michael J., Hoffmann, Markus, Kochs, Georg, Gripp, Barbara, Weigang, Sebastian, Adams, Constantin, Carpinteiro, Elisa, Gulbins, Anne, Keitsch, Simone, Sehl, Carolin, Soddemann, Matthias, Wilker, Barbara, Kamler, Markus, Bertsch, Thomas, Lang, Karl S., Patel, Sameer, Wilson, Gregory C., Walter, Silke, Hengel, Hartmut, Pöhlmann, Stefan, Lang, Philipp A., Kornhuber, Johannes, Becker, Katrin Anne, Ahmad, Syed A., Fassbender, Klaus, Gulbins, Erich
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598530/
https://ncbi.nlm.nih.gov/pubmed/33163980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100142
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