Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2

Sphingosine has been shown to prevent and eliminate bacterial infections of the respiratory tract, but it is unknown whether sphingosine can be also employed to prevent viral infections. To test this hypothesis, we analyzed whether sphingosine regulates the infection of cultured and freshly isolated...

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izdano v:J Biol Chem
Main Authors: Edwards, Michael J., Becker, Katrin Anne, Gripp, Barbara, Hoffmann, Markus, Keitsch, Simone, Wilker, Barbara, Soddemann, Matthias, Gulbins, Anne, Carpinteiro, Elisa, Patel, Sameer H., Wilson, Gregory C., Pöhlmann, Stefan, Walter, Silke, Fassbender, Klaus, Ahmad, Syed A., Carpinteiro, Alexander, Gulbins, Erich
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2020
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650243/
https://ncbi.nlm.nih.gov/pubmed/32917722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015249
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