Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells

The acid sphingomyelinase/ceramide system has been shown to be important for cellular infection with at least some viruses, for instance, rhinovirus or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Functional inhibition of the acid sphingomyelinase using tricyclic antidepressants pre...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Carpinteiro, Alexander, Gripp, Barbara, Hoffmann, Markus, Pöhlmann, Stefan, Hoertel, Nicolas, Edwards, Michael J., Kamler, Markus, Kornhuber, Johannes, Becker, Katrin Anne, Gulbins, Erich
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062550/
https://ncbi.nlm.nih.gov/pubmed/33895135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100701
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