Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells

The acid sphingomyelinase/ceramide system plays an important role in bacterial and viral infections. Here, we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline or genetic downregulation of the e...

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Detalhes bibliográficos
Publicado no:Cell Rep Med
Main Authors: Carpinteiro, Alexander, Edwards, Michael J., Hoffmann, Markus, Kochs, Georg, Gripp, Barbara, Weigang, Sebastian, Adams, Constantin, Carpinteiro, Elisa, Gulbins, Anne, Keitsch, Simone, Sehl, Carolin, Soddemann, Matthias, Wilker, Barbara, Kamler, Markus, Bertsch, Thomas, Lang, Karl S., Patel, Sameer, Wilson, Gregory C., Walter, Silke, Hengel, Hartmut, Pöhlmann, Stefan, Lang, Philipp A., Kornhuber, Johannes, Becker, Katrin Anne, Ahmad, Syed A., Fassbender, Klaus, Gulbins, Erich
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598530/
https://ncbi.nlm.nih.gov/pubmed/33163980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2020.100142
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