Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2

Sphingosine has been shown to prevent and eliminate bacterial infections of the respiratory tract, but it is unknown whether sphingosine can be also employed to prevent viral infections. To test this hypothesis, we analyzed whether sphingosine regulates the infection of cultured and freshly isolated...

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發表在:J Biol Chem
Main Authors: Edwards, Michael J., Becker, Katrin Anne, Gripp, Barbara, Hoffmann, Markus, Keitsch, Simone, Wilker, Barbara, Soddemann, Matthias, Gulbins, Anne, Carpinteiro, Elisa, Patel, Sameer H., Wilson, Gregory C., Pöhlmann, Stefan, Walter, Silke, Fassbender, Klaus, Ahmad, Syed A., Carpinteiro, Alexander, Gulbins, Erich
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650243/
https://ncbi.nlm.nih.gov/pubmed/32917722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015249
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