mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

BACKGROUND: Therapeutic vaccinations against cancer have mainly targeted differentiation antigens, cancer-testis antigens, and overexpressed antigens and have thus far resulted in little clinical benefit. Studies conducted by multiple groups have demonstrated that T cells recognizing neoantigens are...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Cafri, Gal, Gartner, Jared J., Zaks, Tal, Hopson, Kristen, Levin, Noam, Paria, Biman C., Parkhurst, Maria R., Yossef, Rami, Lowery, Frank J., Jafferji, Mohammad S., Prickett, Todd D., Goff, Stephanie L., McGowan, Christine T., Seitter, Samantha, Shindorf, Mackenzie L., Parikh, Anup, Chatani, Praveen D., Robbins, Paul F., Rosenberg, Steven A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
Soggetti:
Clinical Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598064/
https://ncbi.nlm.nih.gov/pubmed/33016924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134915
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