mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

BACKGROUND: Therapeutic vaccinations against cancer have mainly targeted differentiation antigens, cancer-testis antigens, and overexpressed antigens and have thus far resulted in little clinical benefit. Studies conducted by multiple groups have demonstrated that T cells recognizing neoantigens are...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Cafri, Gal, Gartner, Jared J., Zaks, Tal, Hopson, Kristen, Levin, Noam, Paria, Biman C., Parkhurst, Maria R., Yossef, Rami, Lowery, Frank J., Jafferji, Mohammad S., Prickett, Todd D., Goff, Stephanie L., McGowan, Christine T., Seitter, Samantha, Shindorf, Mackenzie L., Parikh, Anup, Chatani, Praveen D., Robbins, Paul F., Rosenberg, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598064/
https://ncbi.nlm.nih.gov/pubmed/33016924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134915
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