mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

BACKGROUND: Therapeutic vaccinations against cancer have mainly targeted differentiation antigens, cancer-testis antigens, and overexpressed antigens and have thus far resulted in little clinical benefit. Studies conducted by multiple groups have demonstrated that T cells recognizing neoantigens are...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Cafri, Gal, Gartner, Jared J., Zaks, Tal, Hopson, Kristen, Levin, Noam, Paria, Biman C., Parkhurst, Maria R., Yossef, Rami, Lowery, Frank J., Jafferji, Mohammad S., Prickett, Todd D., Goff, Stephanie L., McGowan, Christine T., Seitter, Samantha, Shindorf, Mackenzie L., Parikh, Anup, Chatani, Praveen D., Robbins, Paul F., Rosenberg, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
Schlagworte:
Clinical Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598064/
https://ncbi.nlm.nih.gov/pubmed/33016924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134915
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