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Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance

The essential role of reverse transcription in the HIV life cycle is illustrated by the fact that half of the ~30 FDA-approved drugs for HIV treatment target HIV-1 reverse transcriptase (RT). Even though more than 160 structures of RT deposited in the Protein Data Bank (PDB) have revealed the molecu...

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Dettagli Bibliografici
Pubblicato in:Curr Opin Struct Biol
Autori principali: Ruiz, F Xavier, Arnold, Eddy
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596924/
https://ncbi.nlm.nih.gov/pubmed/31935541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2019.11.011
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