Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis

Hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) is a ferroptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX)/Phosphatidylethanolamine Binding Protein-1 (PEBP1) complex or via an Fe-catalyzed non-enzymatic radical reaction. Ferrostatin-1 (Fer-1), a common f...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Anthonymuthu, Tamil S., Tyurina, Yulia Y., Sun, Wan-Yang, Mikulska-Ruminska, Karolina, Shrivastava, Indira H., Tyurin, Vladimir A., Cinemre, Fatma B., Dar, Haider H., VanDemark, Andrew P., Holman, Theodore R., Sadovsky, Yoel, Stockwell, Brent R., He, Rong-Rong, Bahar, Ivet, Bayır, Hülya, Kagan, Valerian E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596334/
https://ncbi.nlm.nih.gov/pubmed/33126055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101744
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