Topoisomerase IIβ targets DNA crossovers formed between distant homologous sites to induce chromatin opening

Type II DNA topoisomerases (topo II) flip the spatial positions of two DNA duplexes, called G- and T- segments, by a cleavage-passage-resealing mechanism. In living cells, these DNA segments can be derived from distant sites on the same chromosome. Due to lack of proper methodology, however, no dire...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Miyaji, Mary, Furuta, Ryohei, Hosoya, Osamu, Sano, Kuniaki, Hara, Norikazu, Kuwano, Ryozo, Kang, Jiyoung, Tateno, Masaru, Tsutsui, Kimiko M., Tsutsui, Ken
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596052/
https://ncbi.nlm.nih.gov/pubmed/33122676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75004-w
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