Enhancer variants associated with Alzheimer’s disease affect gene expression via chromatin looping

BACKGROUND: Genome-wide association studies (GWASs) have identified single-nucleotide polymorphisms (SNPs) that may be genetic factors underlying Alzheimer’s disease (AD). However, how these AD-associated SNPs (AD SNPs) contribute to the pathogenesis of this disease is poorly understood because most...

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Pubblicato in:BMC Med Genomics
Autori principali: Kikuchi, Masataka, Hara, Norikazu, Hasegawa, Mai, Miyashita, Akinori, Kuwano, Ryozo, Ikeuchi, Takeshi, Nakaya, Akihiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734281/
https://ncbi.nlm.nih.gov/pubmed/31500627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-019-0574-8
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