A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease

BACKGROUND: Late-onset Alzheimer’s disease (LOAD), the most common form of dementia, results from complicated interactions among multiple environmental and genetic factors. Despite recent advances in genetic analysis of LOAD, more than half of the heritability for the disease remains unclear. Althou...

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Bibliografiske detaljer
Udgivet i:Mol Med
Main Authors: Asanomi, Yuya, Shigemizu, Daichi, Miyashita, Akinori, Mitsumori, Risa, Mori, Taiki, Hara, Norikazu, Ito, Kaoru, Niida, Shumpei, Ikeuchi, Takeshi, Ozaki, Kouichi
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6585023/
https://ncbi.nlm.nih.gov/pubmed/31216982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-019-0090-5
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