A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease

BACKGROUND: Late-onset Alzheimer’s disease (LOAD), the most common form of dementia, results from complicated interactions among multiple environmental and genetic factors. Despite recent advances in genetic analysis of LOAD, more than half of the heritability for the disease remains unclear. Althou...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Asanomi, Yuya, Shigemizu, Daichi, Miyashita, Akinori, Mitsumori, Risa, Mori, Taiki, Hara, Norikazu, Ito, Kaoru, Niida, Shumpei, Ikeuchi, Takeshi, Ozaki, Kouichi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6585023/
https://ncbi.nlm.nih.gov/pubmed/31216982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-019-0090-5
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