Early-Onset Familial Alzheimer Disease Variant PSEN2 N141I Heterozygosity is Associated with Altered Microglia Phenotype

BACKGROUND: Early-onset familial Alzheimer disease (EOFAD) is caused by heterozygous variants in the presenilin 1 (PSEN1), presenilin 2 (PSEN2), and APP genes. Decades after their discovery, the mechanisms by which these genes cause Alzheimer’s disease (AD) or promote AD progression are not fully un...

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Detalles Bibliográficos
Publicado en:J Alzheimers Dis
Main Authors: Fung, Susan, Smith, Carole L., Prater, Katherine E., Case, Amanda, Green, Kevin, Osnis, Leah, Winston, Chloe, Kinoshita, Yoshito, Sopher, Bryce, Morrison, Richard S., Garden, Gwenn A., Jayadev, Suman
Formato: Artigo
Idioma:Inglês
Publicado: IOS Press 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592656/
https://ncbi.nlm.nih.gov/pubmed/32741831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-200492
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