Early-Onset Familial Alzheimer Disease Variant PSEN2 N141I Heterozygosity is Associated with Altered Microglia Phenotype

BACKGROUND: Early-onset familial Alzheimer disease (EOFAD) is caused by heterozygous variants in the presenilin 1 (PSEN1), presenilin 2 (PSEN2), and APP genes. Decades after their discovery, the mechanisms by which these genes cause Alzheimer’s disease (AD) or promote AD progression are not fully un...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Fung, Susan, Smith, Carole L., Prater, Katherine E., Case, Amanda, Green, Kevin, Osnis, Leah, Winston, Chloe, Kinoshita, Yoshito, Sopher, Bryce, Morrison, Richard S., Garden, Gwenn A., Jayadev, Suman
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592656/
https://ncbi.nlm.nih.gov/pubmed/32741831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-200492
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados