Presenilin 2 Is the Predominant γ-Secretase in Microglia and Modulates Cytokine Release

Presenilin 1 (PS1) and Presenilin 2 (PS2) are the enzymatic component of the γ-secretase complex that cleaves amyloid precursor protein (APP) to release amyloid beta (Aβ) peptide. PS deficiency in mice results in neuroinflammation and neurodegeneration in the absence of accumulated Aβ. We hypothesiz...

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Detalhes bibliográficos
Main Authors: Jayadev, Suman, Case, Amanda, Eastman, Alison J., Nguyen, Huy, Pollak, Julia, Wiley, Jesse C., Möller, Thomas, Morrison, Richard S., Garden, Gwenn A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012089/
https://ncbi.nlm.nih.gov/pubmed/21206757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015743
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