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Toward Drug-Like Multispecific Antibodies by Design

The success of antibody therapeutics is strongly influenced by their multifunctional nature that couples antigen recognition mediated by their variable regions with effector functions and half-life extension mediated by a subset of their constant regions. Nevertheless, the monospecific IgG format is...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Sawant, Manali S., Streu, Craig N., Wu, Lina, Tessier, Peter M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589779/
https://ncbi.nlm.nih.gov/pubmed/33053650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207496
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