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Physicochemical rules for identifying monoclonal antibodies with drug-like specificity

The ability of antibodies to recognize their target antigens with high specificity is fundamental to their natural function. Nevertheless, therapeutic antibodies display variable and difficult-to-predict levels of non-specific and self-interactions that can lead to various drug development challenge...

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Bibliografiske detaljer
Udgivet i:Mol Pharm
Main Authors: Zhang, Yulei, Wu, Lina, Gupta, Priyanka, Desai, Alec A., Smith, Matthew D., Rabia, Lilia A., Ludwig, Seth D., Tessier, Peter M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936472/
https://ncbi.nlm.nih.gov/pubmed/32453957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.0c00257
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