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Net charge of antibody complementarity-determining regions is a key predictor of specificity
Specificity is one of the most important and complex properties that is central to both natural antibody function and therapeutic antibody efficacy. However, it has proven extremely challenging to define robust guidelines for predicting antibody specificity. Here we evaluated the physicochemical det...
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| Publicado no: | Protein Eng Des Sel |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6524611/ https://ncbi.nlm.nih.gov/pubmed/30770934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzz002 |
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