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Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs

Antibodies commonly accumulate charged mutations in their complementarity-determining regions (CDRs) during affinity maturation to enhance electrostatic interactions. However, charged mutations can mediate non-specific interactions, and it is unclear to what extent CDRs can accumulate charged residu...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Tiller, Kathryn E., Li, Lijuan, Kumar, Sandeep, Julian, Mark C., Garde, Shekhar, Tessier, Peter M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633126/
https://ncbi.nlm.nih.gov/pubmed/28778924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.783837
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