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Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs
Antibodies commonly accumulate charged mutations in their complementarity-determining regions (CDRs) during affinity maturation to enhance electrostatic interactions. However, charged mutations can mediate non-specific interactions, and it is unclear to what extent CDRs can accumulate charged residu...
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| Gepubliceerd in: | J Biol Chem |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Biochemistry and Molecular Biology
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5633126/ https://ncbi.nlm.nih.gov/pubmed/28778924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.783837 |
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