Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability

Por Julian, Mark C., Li, Lijuan, Garde, Shekhar, Wilen, Rebecca, Tessier, Peter M.
Publicado no Sci Rep (2017)

Net charge of antibody complementarity-determining regions is a key predictor of specificity

Por Rabia, Lilia A, Zhang, Yulei, Ludwig, Seth D, Julian, Mark C, Tessier, Peter M
Publicado no Protein Eng Des Sel (2018)

Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs

Por Tiller, Kathryn E., Li, Lijuan, Kumar, Sandeep, Julian, Mark C., Garde, Shekhar, Tessier, Peter M.
Publicado no J Biol Chem (2017)

Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies

Por Julian, Mark C., Lee, Christine C., Tiller, Kathryn E., Rabia, Lilia A., Day, Evan K., Schick, Arthur J., Tessier, Peter M.
Publicado no Protein Eng Des Sel (2015)

Nature-inspired design and evolution of anti-amyloid antibodies

Por Julian, Mark C., Rabia, Lilia A., Desai, Alec A., Arsiwala, Ammar, Gerson, Julia E., Paulson, Henry L., Kane, Ravi S., Tessier, Peter M.
Publicado no J Biol Chem (2019)

Design and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid Polypeptide

Por Lee, Christine C., Julian, Mark C., Tiller, Kathryn E., Meng, Fanling, DuConge, Sarah E., Akter, Rehana, Raleigh, Daniel P., Tessier, Peter M.
Publicado no J Biol Chem (2016)