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Tafazzin Mutation Affecting Cardiolipin Leads to Increased Mitochondrial Superoxide Anions and Mitophagy Inhibition in Barth Syndrome

Tafazzin is a phospholipid transacylase that catalyzes the remodeling of cardiolipin, a mitochondrial phospholipid required for oxidative phosphorylation. Mutations of the tafazzin gene cause Barth syndrome, which is characterized by mitochondrial dysfunction and dilated cardiomyopathy, leading to p...

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Опубликовано в: :Cells
Главные авторы: Petit, Patrice X., Ardilla-Osorio, Hector, Penalvia, Lucile, Nathan E., Rainey
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589545/
https://ncbi.nlm.nih.gov/pubmed/33096711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9102333
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