Deletion of the Cardiolipin-specific Phospholipase Cld1 Rescues Growth and Life Span Defects in the Tafazzin Mutant: IMPLICATIONS FOR BARTH SYNDROME

Cardiolipin (CL) that is synthesized de novo is deacylated to monolysocardiolipin (MLCL), which is reacylated by tafazzin. Remodeled CL contains mostly unsaturated fatty acids. In eukaryotes, loss of tafazzin leads to growth and respiration defects, and in humans, this results in the life-threatenin...

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Detalhes bibliográficos
Main Authors: Ye, Cunqi, Lou, Wenjia, Li, Yiran, Chatzispyrou, Iliana A., Hüttemann, Maik, Lee, Icksoo, Houtkooper, Riekelt H., Vaz, Frédéric M., Chen, Shuliang, Greenberg, Miriam L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916517/
https://ncbi.nlm.nih.gov/pubmed/24318983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.529487
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