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Tafazzin Mutation Affecting Cardiolipin Leads to Increased Mitochondrial Superoxide Anions and Mitophagy Inhibition in Barth Syndrome

Tafazzin is a phospholipid transacylase that catalyzes the remodeling of cardiolipin, a mitochondrial phospholipid required for oxidative phosphorylation. Mutations of the tafazzin gene cause Barth syndrome, which is characterized by mitochondrial dysfunction and dilated cardiomyopathy, leading to p...

詳細記述

保存先:
書誌詳細
出版年:Cells
主要な著者: Petit, Patrice X., Ardilla-Osorio, Hector, Penalvia, Lucile, Nathan E., Rainey
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589545/
https://ncbi.nlm.nih.gov/pubmed/33096711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9102333
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