The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells

The chromatin-binding E3 ubiquitin ligase ubiquitin-like with PHD and RING finger domains 1 (UHRF1) contributes to the maintenance of aberrant DNA methylation patterning in cancer cells through multivalent histone and DNA recognition. The tandem Tudor domain (TTD) of UHRF1 is well-characterized as a...

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Détails bibliographiques
Publié dans:Epigenetics Chromatin
Auteurs principaux: Vaughan, Robert M., Kupai, Ariana, Foley, Caroline A., Sagum, Cari A., Tibben, Bailey M., Eden, Hope E., Tiedemann, Rochelle L., Berryhill, Christine A., Patel, Varun, Shaw, Kevin M., Krajewski, Krzysztof, Strahl, Brian D., Bedford, Mark T., Frye, Stephen V., Dickson, Bradley M., Rothbart, Scott B.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585203/
https://ncbi.nlm.nih.gov/pubmed/33097091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-020-00366-4
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